HIV-1 and human genetic variation

Genetic Variation in MMP-1 Promoter Region and

Hiv-1 Phenotype and Genetic Variation in Vertical Transmission

HIV-1 vertical transmission is increasing worldwide despite that successful strategies are available. Reduction of vertical transmission has been established by antiretroviral prophylaxis and elective Caesarian section, but this has been limited to the developed countries. In the developing world the lack of resources, the necessity of breastfeeding, social and ethical factors, have all contrib...

Human genetic polymorphisms affecting HIV-1 diseases.

Human immunodeficiency virus type 1 (HIV-1) infection is generally characterized by a long-term, chronic disease course that gradually progresses to acquired immunodeficiency syndrome (AIDS). However, a small fraction of HIV-1-infected individuals remain both clinically and immunologically healthy for 10 years or more after seroconversion. Conversely, the disease of another significant fraction...

Impact of Tat Genetic Variation on HIV-1 Disease

The human immunodeficiency virus type 1 (HIV-1) promoter or long-terminal repeat (LTR) regulates viral gene expression by interacting with multiple viral and host factors. The viral transactivator protein Tat plays an important role in transcriptional activation of HIV-1 gene expression. Functional domains of Tat and its interaction with transactivation response element RNA and cellular transcr...

Running Head : GENETIC VARIATION IN CHT 1 AND HUMAN ATTENTION

This study examined the contributions of genetic variation to individual differences in ability to pay attention. Specifically, we examined a subcapacity version (Ile89Val) of the high affinity choline transporter, a protein important in regulating the brain’s acetylcholine levels, and tested the hypothesis that it would influence the ability to modulate attention. In Experiment 1, subjects wer...